What is Cardiac Amyloidosis?

  • Systemic amyloidosis constitutes a group of diseases in which normally soluble plasma proteins are deposited in the extracellular space in an abnormal insoluble form, and can affect virtually any organ, including the heart.
  • Amyloid deposition in the heart causes a cardiomyopathy. Cardiomyopathy is an acquired disease of the heart muscle which makes it difficult for the heart to pump blood to other parts of the body.
  • Most cases of cardiac amyloidosis are caused mainly caused by AL Amyloidosis or TTR amyloidosis
  • AL amyloidosis: misfolded monoclonal immunoglobulin light chains (AL) from an abnormal clonal proliferation of plasma cells.
  • TTR amyloidosis: transthyretin (TTR) amyloidosis, a liver synthesized protein that is normally involved in the transportation of the hormone thyroxine and retinol-binding protein.

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